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It is widely used within the pharmaceutical, food, and cosmetic sectors as a formulation aid. Created Date: 2/10/2020 8:51:41 PM . Go to Investor Relations. Material Safety Data Sheet Ethyl Alcohol 70 ACC 91791 April 21st, 2019 - Material Safety Data Sheet Ethyl Alcohol 70 ACC 91791 Section 1 Chemical Product and Company Identification Ethanol has been shown to produce fetotoxicity in the embry o or fetus of laboratory animals Prenatal Chemical waste generators must determine However, if handling bulk powders, observance of appropriate safeguards is recommended. It . Molecular Weight null. undefined. Although the breakup of cellulose to form colloidal microcrystalline cellulose has no impact on calorific content of the material, colloidal microcrystalline cellulose contain soluble components (hydrocolloids) that are introduced during processing, which add calories to the product. Our customers around the world enjoy the benefits of TEXTURECEL NaCMC in various wound care products, too. w !1AQaq"2B #3Rbr % The table below shows the most common physicochemical parameters of this raw material. ( LATTICE Microcrystalline Cellulose has many important uses within the food, pharma, specialty applications and industrial such as non-stick coatings, insulation of wiring, crop protection and paints,coats and inks. The data shown below apply only to Avicel PH 101. No. A schematic illustration of the manufacturing process for Avicel Microcrystalline cellulose is shown below. Microcrystalline Cellulose, Colloidal Silicon Dioxide: 50: 0.20 - 0.30: Best in class binder. ChemicalBook. Eur., JPE . <> Page 1 of 8. In Cellulose and Cellulose Derivatives in the Food Industry, T. Wstenberg (Ed. stream Magazine: Material safety data sheet - FMC Corporation. 51395-75-6 Avicel RC 591. %PDF-1.4 1 0 obj q86@on$^X_HuH;3` 1 0 obj Upon ingestion, microcrystalline cellulose is not absorbed into the blood stream and therefore has little toxicological potential. Superior Performance: Provides excellent water uptake and rapid swelling . /Group << /S /Transparency /CS /DeviceRGB /I false /K false >> IDENTIFICATION OF THE SUBSTANCE/MIXTURE AND OF THE COMPANY/UNDERTAKING 1.1 Product identifiers Product name : Avicel PH-101 Product Number : 11365 Brand : Fluka CAS-No. bEI3%UxI"M_1)5b/c;/\~3:?/9S\\9/%I3nn2foO^MgX0n: O % /Parent 3 0 R All rights reserved. Microcrystalline cellulose is a commonly used excipient in the . : 9 This document has been prepared to meet the requirements of the U.S. OSHA Hazard Communication . It is also used in plaque assays for counting. JFIF ` ` ZExif MM * J Q Q Q C Kristensen, T. Schfer, P. Kleinebudde, Direct pelletization in a rotary processor controlled by torque measurements. Avicel is one of the best-known pharmaceutical excipient brands and, without doubt, one of the most frequently used raw materials in solid oral product formulation and manufacture. Microcrystalline cellulose (Avicel, FMC Corporation) is prepared by acid hydrolysis of cellulose using 2 M hydrochloric acid at 105 C for 15 min. Dyvo5bp#bR W7~IF C" d6zLz~!#>@HO}sx;hm>> Fmc Corporation: Ultra-fine microcrystalline cellulose compositions and process . . *r_ *?~4$ &0Y# Manufactured by: China . This paper is based on a study of the interactions that take place during the process of hydrogel formation, break down, and recovery. Are you looking for information about products and services by region? Learn about our new global sustainability platform, Learn about FMC's industry leading goal of net-zero emissions by 2035, Learn about FMC's differentiated biologically-based crop solutions. endobj Alubra is also less susceptible to over-blending contributing to more flexible process conditions and reduced waste due to over blended batch failures. Well-recognized product that can do it all. There may be more fiber in your food than you realized. They are high molecular weight, highly sulfated, linear molecules with a galactose backbone. Learn about FMC's differentiated biologically-based crop solutions. In roller compaction, Avicel Microcrystalline cellulose improves compaction during the ribbon phase, enabling a trouble-free process while also preserving the plasticity of the compacts. CAS #: 9004-34-6 1.6. Ac-Di-Sol Croscarmellose Sodium is one of our flagship offerings for pharmaceutical manufacturers. Avicel Microcrystalline cellulose is manufactured in the United States of America by Dupont. ?t#_n|z%4n#(!:lMD~{mfvv}Na0vx?? Unique functionality for a broad range of pharmaceutical applications. Htn@sHaYoEJ*H[G&o)o9;0s N'3[*%M]vAu#9Tqpg9D& [FMC Study Number I92-1464]. Accumulation of overhead settled dust may form explosive concentrations in air when disturbed and dispersed. Heavy metals, % NMT 0.001 Avicel Microcrystalline cellulose was discovered in 1955 by a team at FMC Corporation, led by the legendary Canadian-born chemist, Orlando Aloysius Battista, which he initially named mechanically disintegrated D.P cellulose. Regulatory Information The aqueous solution to barrier membrane coating. HAZARDS IDENTIFICATION EMERGENCY TELEPHONE NUMBERS (302) 451-0100 (FMC Plant - Newark, Delaware) (303) 595-9048 (Medical - U.S. - Call Collect) For leak, fire, spill, or accident emergencies, call: (800) 424-9300 (CHEMTREC - U.S.A. & Canada) (703) 527-3887 (CHEMTREC - Collect - All Other Countries) EMERGENCY OVERVIEW: Off-white, free-flowing, odorless powder. FMC, JRS and Mingtai were estimated to hold for . EINECS #: 232-674-9 1.7. CoA. Material safety data sheet - FMC Corporation. Revision No. . Explore how you can develop your career and bring your creative ideas to life at IFF. gac74 [#B6`Wnw7 Hi, let us know if you have any questions as you visit our website. /Producer(Sub Systems, Inc.)/CreationDate(D:20211228124915+05'00')/ModDate(D:20211228124915+05'00')/Creator(Sub Systems, Inc.) Microcrystalline cellulose has excellent compressibility properties and is widely used in solid forms such as tablets that are hard, but can dissolve quickly, and this has increased its demand in . on Avicel microcrystalline cellulose, the most trusted excipient brand for decades. II: effects of changes in the content of Microcrystalline Cellulose, AAPS PharmSci, 2 (2000) 45. Manufacturer: FMC BioPolymer. . P}MFbN#[>r(y Alubra sodium stearyl fumarate from IFF Pharma Solutions is a comparatively hydrophilic lubricant widely used in capsule and tablet formulations. Copyright 2023 by International Flavors & Fragrances Inc. IFF is a Registered Trademark. \C[i+rY2$V,,WT#_)3K?=/fW%[,lE"V?C PipEAz_xO;`cZsC0qcx;@tp]c*T7ge @Mty?]@SNmpf/]q#I,G1I?SR.@z*Xb KjR hb{T$CQrr Yx%O@~57eL5S\r-|EZ)Y.C]KuIlW]@12KY,S]C"e%b*|YX122igjl; @! ,}b;XQ})+l{~d_=sUtl V"CbKas+;fc>]bt#F,Md]]!5xae ;}rr^NI]rUc^,5Lc(fyyp*a=~U}WveuTLYX/ _V{#* g(*Rrm0gyv9i@0UT:A+{eW/y BS3_!Qv rt^BN! Avicel Microcrystalline cellulose is a type of cellulose, a naturally-occurring, large molecular weight polysaccharide found in woody plants. Dupont acquired the microcrystalline cellulose business of FMC Corporation in 2017. Burger King, McDonald's and other fast food companies list in the ingredients of several of their foods, microcrystalline cellulose (MCC . CAS 9004-34-6. Pharmacel 112 can be used in a wide range of oral solid dosage (OSD) forms as binder, compressing agent . Further elaborations can then be performed on the obtained material to produce many other grades of Microcrystalline cellulose. 86dXeaAjHe%d*`&>>&_p}=X|_% fTtC aB s!YaxHWtGr"GQ 5S"fMS+_;x@@5 zjrK=;OA:il)b> e ei'wm~oh!=Z@Y:J0#8On`T./iC}^o%7KS"$ rf*Z;JTL-uOHH%%Z,029J_ ( endstream endobj 526 0 obj 465 endobj 527 0 obj << /Filter /FlateDecode /Length 526 0 R >> stream Cellulose is a linear polymer of -D-glucose, linked through carbon atoms 1 and 4. Combines good flow and high compactibility. A., and Smith, P. A. Catalog Number 102331. The global microcrystalline cellulose (MCC) market was valued at $401.1 million in 2021, and is projected to reach $712.9 million by 2031, growing at a CAGR of 5.9% from 2022 to 2031. Medium size standard MCC grade, suited for the majority of directly compressible actives. ( Microcrystalline cellulose (C6H10O5)n is refined wood pulp. Microcrystalline cellulose (MCC) for industrial purposes is usually obtained from wood pulp and purified cotton linters. Microcrystalline cellulose -The oldest polymer finds new industrial uses,. Test Data Available. % The figure below illustrates the structural organisation of cellulose within plants. }[eD-1-8$#Yi^$o8Nc6vwfw;wBT~[Rgi1?%T*/J:/'+Gf'Ae*j@{Rh+2oN|Sbtt;z#v8})F#z=:*]q+U>+ .e ^Q-{@ RPC t/(If>8P&%wNPMJw,VI2aUqRqe3bC,a;C&4RQSf*(=I$r{'%jmk1LUZV(*is6r&wQPAAoID4p?,"lp:wE+)v(_w 'yelVnMh=gIYjK:9v{$G;b8=lGG1_,h^0F2`a~Kusz1p#NS*qt6,F:7+Rma-4u} DINFzJ"Mlctg*~HEge Co-processed excipients deliver functional synergies to address formulation challenges with simplified, single ingredient solutions. cas:9032-51-3 msds CELLULOSE PAB. LATTICE Microcrystalline Cellulose has many important uses within the food, pharma, specialty applications and industrial such . SDS - Safety Data Sheet. All Rights Reserved. The cellulose molecule is formed through repeated condensation of cellobiose units. AVICEL RC 581. Aqueous suspensions of microcrystalline cellulose have . Alginate drug delivery harnesses the unique properties of seaweed for premier performance in multiple pharmaceutical and nutraceutical applications; they impart viscosity in solutions and even form a three-dimensional gel in the presence of calcium ions. Microcrystalline cellulose 9004-34-6 <1 Synonyms are provided in Section 1. Earth Supplied Products LLC. endobj The fumarate moiety of Alubra increases its melting temperature, which allows for greater functionality at high press speeds while the stearate chain maintains the lubricity of the compound and supports low ejection forces. However, consumption of large quantities of the material may have a laxative effect. PharmaCentral 2021 . MATERIAL SAFETY DATA SHEET Avicel PH Microcrystalline Cellulose MSDS Ref. Avicel co-processed products are high functionality excipients offering improved powder flow, granule properties, tablet compression, and mouth feel. Trademarks: Avicel PH-102. An internally cross-linked sodium carboxymethyl cellulose (NaCMC), it aids in the disintegration and drug dissolution of pharmaceutical tablets, capsules, and granules. It is an excipient approved for use in pharmaceutical products and is also GRAS listed and accepted for use as a food additive in Europe and the United States and is included in the FDA Inactive Ingredients Database (oral: powders, suspensions, syrups, and tablets; topical & vaginal products). FMC BioPolymer 1735 Market Street Philadelphia, PA 19103 (800) 526-3649 . } !1AQa"q2#BR$3br The 'Substance identity' section is calculated from substance identification information from all ECHA databases. 3t;zAXa[j.7ZX[GL9e,>6sVV`T6`#W MATERIAL SAFETY DATA SHEET Avicel PC 611 Microcrystalline Cellulose Page 1 of 8 MSDS Ref. Microcrystalline cellulose was negative in the Ames mutagenicity assay [FMC Study Number I91-1189], and caused no They are soluble in a wide range of organic solvents, beginning with aliphatic alcohols such as ethanol and isopropanol, and are compatible with most other familiar organic solvent chemistries, including ether alcohols, ketones, aromatic hydrocarbons and many more. Fiber supplements can lessen the absorption of some . gwf;J(e0o|1p{R~P^);ao!%{0KD7. This Microcrystalline Cellulose . Microcrystalline cellulose is produced by subjecting to a high shear treatment, at elevated temperature and pressure, a reaction mixture of a cellulose material, an active oxygen compound and water, for a time effective to depolymerize the cellulose material. This is unlikely to be a problem when Microcrystalline cellulose is consumed as part of a medical product where it is used as an excipient in the formulation. Molecular weight: Not Applicable 1.5. The representative usage of Avicel PH-101 and Avicel PH-102 Microcrystalline cellulose in wet granulation and direct compression is shown in the following two examples. << Buy Chemicals. It does not interfere with other nutrients when added to food products, and is instead, an excellent carrier and stabiliser, helping prolong the viability of food products. Van Veen, G.K. Bolhuis, Y.S. BIOACCUMULATIVE POTENTIAL %&'()*456789:CDEFGHIJSTUVWXYZcdefghijstuvwxyz We know that our customers need to provide reliable and consistent products to their patients. %PDF-1.4 Same quality to grades 102/90M, but very low moisture content (< 1.5 %) for processing water-sensitive actives. Avicel Microcrystalline Cellulose: Chemical Identifiers. Validity Area. The smallest units, the elementary fibrils (cellulose crystalline strands) are made up of many -(1-4) glucose chains which are bundled to form microfibrils. iq/iVO"5VI}dn.#q^(fJ),BN yb5*4reh1"!E?mR*%fK,e4?A\{OAXr1' tx&Ul{J,57n%PV E2eMS5'UOL wdD{s)4N-m ab K * ~CVHg}{J2.M}O)^}|Z{V+ >AW|? eqgP}OF'v7heLP&Y,eoo`x7lR}0iRVP],=`_2rS'*X$b)+XV2;fbQDgkgx:IZ|v>lDD/TDqz %RL Non-woody sources are also viable sources of cellulose, although only woody plants and cotton are the main sources for microcrystalline cellulose used as a pharmaceutical excipient. SUBSTANCE IDENTIFICATION 1.1. The polymers added organosolubility further creates advantages for employing HPMC in solvent spray-drying applications. Powder becomes slippery when wet. EMCOCEL 90 M. 130. It is generally regarded as a relatively nontoxic and non-irritant material that is safe for human and animal consumption. As one of the most robust and efficient excipients, it tolerates high salt content, high temperature and is stable in a wide pH range. Product Name: MICROCRYSTALLINE CELLULOSE Date/ Revised: 27/November/2012 Page 1 of 4 1. q9;v80 5 0 obj : 9004-34-6 1.2 Relevant identified uses of the substance or mixture and uses advised against 10.1 Future Forecast of the Global Microcrystalline Cellulose Market from 2023-2028 Segment by Region 10.2 Global Microcrystalline Cellulose Production and Growth Rate Forecast by Type (2023-2028 . They are made up of sulfated and non-sulfated repeating units of galactose and 3,6-anhydrogalactose. MATERIAL SAFETY DATA SHEET Lattice NT Microcrystalline Cellulose MSDS Ref. Assay: 0.98 Appearance: Off white to slight yellow solid Package: 1L 5L 10L 25L bottle Storage: Stored in shaded, cool and dry places Transportation: Handle with cares to avoid damaging the packages. The typical mean particle size is 20200 m. Revision No. Chemical Name Microcrystalline cellulose (INCI Name): MCC, cellulose gel Common Name Avicel PH105 Microcrystalline Cellulose CAS Number 9004-34-6 Impurities and/or Stabilizing Additives No data available Section 4: First Aid Measures General Advice No data available If Inhaled Remove person to fresh air. AFFINISOL HPMC HME offers hot melt extrusion process flexibility in choosing a polymer viscosity that optimizes drug release profiles and against the factors affecting solubility. You have already flagged this document.Thank you, for helping us keep this platform clean.The editors will have a look at it as soon as possible. Its used in capsules and tablets, both in wet granulation and direct compression processes, where it serves as a moisture adsorbent, tablet, and capsule diluent, and tablet disintegrant.It is also widely used as a supplementary formulation aid, primarily to enhance the .